National Cancer Institute Thesaurus

Last uploaded: February 21, 2019

Preferred Name	Pramlintide
ID	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61901
CAS_Registry	151126-32-8
Chemical_Formula	C171H267N51O53S2
code	C61901
Concept_In_Subset	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source	FDA
DEFINITION	A peptide analogue of human amylin with 3 proline substitutions at positions 25, 28 and 29, with antihyperglycemic activity. By mimicking amylin, pramlintide slows gastric emptying, inhibits digestive secretions (gastric acid, pancreatic enzymes, and bile), reduces glucagon secretion, and increases satiety; all of these actions are mediated mostly by glucose-sensitive areas in the brain stem. The overall result is a decrease in blood glucose levels. The use of pramlintide may cause an increased risk of insulin-induced hypoglycemia.
FDA_UNII_Code	D3FM8FA78T
FULL_SYN	Triproamylin
Has_Salt_Form	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61902
label	Pramlintide
Legacy_Concept_Name	Pramlintide
Preferred_Name	Pramlintide
prefixIRI	C61901
prefLabel	Pramlintide
Semantic_Type	Pharmacologic Substance
UMLS_CUI	C0537551
subClassOf	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29711

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Delete	Mapping To	Ontology	Source
	http://purl.obolibrary.org/obo/CHEBI_135922	Chemical Entities of Biological Interest Ontology	LOOM
	http://purl.bioontology.org/ontology/MESH/C105254	Medical Subject Headings	LOOM