National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Prominin-1

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C64344

code

C64344

DEFINITION

Prominin-1 (865 aa, ~97 kDa) is encoded by the human PROM1 gene. This protein may play a role in hematopoiesis, but an exact function has yet to be elucidated. The protein has been implicated in tumor pathogenesis and formation in several cancers, including retinoblastoma, hemangioma, and glioblastoma phenotypes. Additionally, the protein has been used as a marker to distinguish cells that have the potential to become cancerous from the larger normal cell population.

FULL_SYN

Antigen AC133

CD133 Antigen

Prominin-like protein 1

CD133

label

Prominin-1

Legacy_Concept_Name

Prominin-1_Protein

OMIM_Number

604365

Preferred_Name

Prominin-1

prefixIRI

C64344

prefLabel

Prominin-1

Semantic_Type

Amino Acid, Peptide, or Protein

Swiss_Prot

O43490

UMLS_CUI

C0673028

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18466

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/OMIM/604365 Online Mendelian Inheritance in Man LOOM
http://purl.obolibrary.org/obo/PR_000001786 Phenotypic Quality Ontology LOOM
http://purl.obolibrary.org/obo/PR_000001786 Cell Ontology LOOM
http://purl.obolibrary.org/obo/PR_000001786 Protein Ontology LOOM
http://purl.obolibrary.org/obo/PR_000001786 Cell Line Ontology Subset for Chinese National Infrastructure of Cell Line Resource (NICR) LOOM
http://purl.obolibrary.org/obo/PR_000001786 Cell Line Ontology (Chinese Translation) LOOM