National Cancer Institute Thesaurus

Last uploaded: February 21, 2019

Preferred Name	Vardenafil
ID	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66650
CAS_Registry	224785-90-4
CHEBI_ID	CHEBI:46295
Chemical_Formula	C23H32N6O4S
code	C66650
Concept_In_Subset	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source	FDA
DEFINITION	A benzenesulfonamide derivative and phosphodiesterase type 5 (PDE5) inhibitor with vasodilatory activity. Vardenafil selectively inhibits PDE5, thus inhibiting the degradation of cyclic guanosine monophosphate (cGMP) found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. The inhibition of cGMP degradation results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, prolonging penile erection.
FDA_UNII_Code	UCE6F4125H
Has_Salt_Form	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C76318 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C76892
label	Vardenafil
Legacy_Concept_Name	Vardenafil
Preferred_Name	Vardenafil
prefixIRI	C66650
prefLabel	Vardenafil
Semantic_Type	Pharmacologic Substance
UMLS_CUI	C0971579
subClassOf	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2127

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_46295	Chemical Entities of Biological Interest Ontology	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU035877	Logical Observation Identifier Names and Codes	LOOM
http://purl.bmicc.cn/ontology/ICD11CN/XM9AZ1	International Classification of Diseases, 11th Edition, China	LOOM
http://purl.bioontology.org/ontology/LNC/LP100060-5	Logical Observation Identifier Names and Codes	LOOM