National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Norgestrel

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C703

Accepted_Therapeutic_Use_For

Oral contraception

CAS_Registry

6533-00-2

CHEBI_ID

CHEBI:50901

CHEBI:7630

Chemical_Formula

C21H28O2

code

C703

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A synthetic progestin commonly used alone or in combination with an estrogen for contraception. Norgestrel suppresses the secretion of luteinizing and follicle-stimulating hormones (LH and FSH), thickens cervical mucus, and slows the transit of ova through the fallopian tubes. This agent also exhibits antiproliferative activity in endometrial tissue and may exhibit chemopreventive and antineoplastic activities in endometrial carcinoma. (NCI04)

Display_Name

Norgestrel

FDA_UNII_Code

3J8Q1747Z2

FULL_SYN

(17alpha)-(+/-)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yne-3-one

(+/-)-13-Ethyl-17alpha-hydroxy-18,19-dinorpregn-4-en-20-yne-3-one

Wy-3707

Neogest

Ovrette

label

Norgestrel

Legacy_Concept_Name

Norgestrel

PDQ_Closed_Trial_Search_ID

39310

PDQ_Open_Trial_Search_ID

39310

Preferred_Name

Norgestrel

prefixIRI

C703

prefLabel

Norgestrel

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0699169

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C776

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http://purl.obolibrary.org/obo/CHEBI_7630 Chemical Entities of Biological Interest Ontology LOOM
http://purl.bioontology.org/ontology/MESH/D009644 Medical Subject Headings LOOM