National Cancer Institute Thesaurus

Last uploaded: February 21, 2019

Preferred Name	Novobiocin
ID	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C705
ALT_DEFINITION	An antibiotic drug used to treat infection.
CAS_Registry	303-81-1
CHEBI_ID	CHEBI:28368
Chemical_Formula	C31H36N2O11
code	C705
Concept_In_Subset	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source	FDA
DEFINITION	An aminocoumarin antibiotic, produced by the actinomycete Streptomyces nivens, with antibacterial property. Novobiocin, as well as other aminocoumarin antibiotics, inhibits bacterial DNA synthesis by targeting at the bacteria DNA gyrase and the related enzyme DNA topoisomerase IV. This antibiotic was used to treat infections by gram-positive bacteria.
FDA_UNII_Code	17EC19951N
Has_Salt_Form	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66247 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C81448
label	Novobiocin
Legacy_Concept_Name	Novobiocin
NSC_Code	2382
PDQ_Closed_Trial_Search_ID	39195
PDQ_Open_Trial_Search_ID	39195
Preferred_Name	Novobiocin
prefixIRI	C705
prefLabel	Novobiocin
Semantic_Type	Organic Chemical Antibiotic
UMLS_CUI	C0028458
subClassOf	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C258

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Mapping To	Ontology	Source
http://purl.bmicc.cn/ontology/ICD11CN/XM1QQ2	International Classification of Diseases, 11th Edition, China	LOOM
http://purl.bioontology.org/ontology/LNC/LP16168-4	Logical Observation Identifier Names and Codes	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU007486	Logical Observation Identifier Names and Codes	LOOM
http://purl.obolibrary.org/obo/CHEBI_28368	Chemical Entities of Biological Interest Ontology	LOOM
http://purl.obolibrary.org/obo/CHEBI_28368	GenEpiO	LOOM
http://purl.bioontology.org/ontology/MESH/D009675	Medical Subject Headings	LOOM