loading...| Preferred Name |
Phosphatidylinositol |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C743 |
| CHEBI_ID |
CHEBI:28874 |
| code |
C743 |
| DEFINITION |
A phosphatidic acid combined with inositol found in biomembranes and a precursor to certain cellular signals. Sometimes referred to as inositide. It is a very important minor phospholipid in eukaryotes, involved in signal transduction processes. Contains myo inositol linked through the 1 hydroxyl group to phosphatidic acid. The 4 phosphate (PIP) and 4, 5 bisphosphate derivatives PIP2) are formed and broken down in membranes by the action of specific kinases and phosphatases (futile cycles). Signal sensitive phospholipase C enzymes remove the inositol moiety, in particular from 1,4,5 trisphosphate (PIP2) as inositol 1,4,5 triphosphate (Ins P3: IP3). Both the diacyl glycerol and products act as second messengers. |
| FULL_SYN |
PI |
| label |
Phosphatidylinositol |
| Legacy_Concept_Name |
Phosphatidylinositol |
| Preferred_Name |
Phosphatidylinositol |
| prefixIRI |
C743 |
| prefLabel |
Phosphatidylinositol |
| Semantic_Type |
Organic Chemical |
| UMLS_CUI |
C0031621 |
| subClassOf |