National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Phosphodiesterase Inhibitor

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C744

ALT_DEFINITION

Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.

CHEBI_ID

CHEBI:50218

code

C744

DEFINITION

Any substance that inhibits phosphodiesterase, an enzyme that catalyzes the breaking of a phosphodiester bond. Usually, this refers to cyclic nucleotide phosphodiesterase, an enzyme that breaks the phosphodiester bond in the second messenger molecules cAMP and cGMP. Inhibition of cyclic nucleotide phosphodiesterase can be used to affect vasodilation.

FULL_SYN

PDE Inhibitor

label

Phosphodiesterase Inhibitor

Legacy_Concept_Name

Phosphodiesterase_Inhibitor

Preferred_Name

Phosphodiesterase Inhibitor

prefixIRI

C744

prefLabel

Phosphodiesterase Inhibitor

Semantic_Type

Chemical Viewed Functionally

UMLS_CUI

C0031638

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C471

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