loading...| Preferred Name |
Alpha-Tocopherol |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C74960 |
| ALT_DEFINITION |
Tocopherol with three methyl groups on its chromanol ring. |
| CAS_Registry |
59-02-9 |
| CHEBI_ID |
CHEBI:18145 |
| Chemical_Formula |
C29H50O2 |
| code |
C74960 |
| Concept_In_Subset | |
| Contributing_Source |
CRCH FDA |
| DEFINITION |
The orally bioavailable alpha form of the naturally-occurring fat-soluble vitamin E, with potent antioxidant and cytoprotective activities. Upon administration, alpha-tocopherol neutralizes free radicals, thereby protecting tissues and organs from oxidative damage. Alpha-tocopherol gets incorporated into biological membranes, prevents protein oxidation and inhibits lipid peroxidation, thereby maintaining cell membrane integrity and protecting the cell against damage. In addition, alpha-tocopherol inhibits the activity of protein kinase C (PKC) and PKC-mediated pathways. Alpha-tocopherol also modulates the expression of various genes, plays a key role in neurological function, inhibits platelet aggregation and enhances vasodilation. Compared with other forms of tocopherol, alpha-tocopherol is the most biologically active form and is the form that is preferentially absorbed and retained in the body. |
| FDA_UNII_Code |
H4N855PNZ1 |
| FULL_SYN |
2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)chroman-6-ol .ALPHA.-TOCOPHEROL 3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol |
| INFOODS |
TOCPHA |
| label |
Alpha-Tocopherol |
| Legacy_Concept_Name |
Alpha-Tocopherol |
| Macronutrient |
Y |
| NSC_Code |
20812 |
| Nutrient |
Y |
| PDQ_Closed_Trial_Search_ID |
775583 |
| PDQ_Open_Trial_Search_ID |
775583 |
| Preferred_Name |
Alpha-Tocopherol |
| prefixIRI |
C74960 |
| prefLabel |
Alpha-Tocopherol |
| Semantic_Type |
Pharmacologic Substance Vitamin |
| UMLS_CUI |
C0969677 |
| Unit |
mg |
| USDA_ID |
323 |
| subClassOf |