National Cancer Institute Thesaurus

Last uploaded: February 21, 2019

Preferred Name	Tavaborole
ID	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C81725
CAS_Registry	174671-46-6
Chemical_Formula	C7H6BFO2
code	C81725
Concept_In_Subset	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source	FDA
DEFINITION	A boron-containing small molecule antifungal agent with broad-spectrum activity against filamentous fungi, including both mold and yeast. 5-Fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole inhibits fungal cytoplasmic leucyl-tRNA synthetase by preventing catalytic turnover, thus inhibiting synthesis of leucyl-tRNA(Leu) and consequentially blocking protein synthesis.
FDA_UNII_Code	K124A4EUQ3
FULL_SYN	5-Fluoro-1,3-Dihydro-1-Hydroxy-2,1-Benzoxaborole AN2690
label	Tavaborole
Legacy_Concept_Name	_5-Fluoro-1_3-Dihydro-1-Hydroxy-2_1-Benzoxaborole
Preferred_Name	Tavaborole
prefixIRI	C81725
prefLabel	Tavaborole
Semantic_Type	Pharmacologic Substance
UMLS_CUI	C1743355
subClassOf	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28394 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C514

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Delete	Mapping To	Ontology	Source
	http://purl.obolibrary.org/obo/CHEBI_77942	Chemical Entities of Biological Interest Ontology	LOOM
	http://purl.bioontology.org/ontology/MESH/C512998	Medical Subject Headings	LOOM