loading...| Preferred Name |
Zabicipril |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82218 |
| CAS_Registry |
83059-56-7 |
| Chemical_Formula |
C23H32N2O5 |
| code |
C82218 |
| Concept_In_Subset | |
| Contributing_Source |
FDA |
| DEFINITION |
A non-thiol angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, zabicipril is rapidly converted in vivo by de-esterification into its active form zabiciprilat. Zabiciprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Zabiciprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. |
| FDA_UNII_Code |
475035SS4C |
| FULL_SYN |
(3S)-2-((2S)-N-((1S)-1-Carboxy-3-phenylpropyl)alanyl)-2-azabicyclo(2.2.2)octane-3-carboxylic Acid, 1-ethyl Ester |
| label |
Zabicipril |
| Legacy_Concept_Name |
Zabicipril |
| Preferred_Name |
Zabicipril |
| prefixIRI |
C82218 |
| prefLabel |
Zabicipril |
| Semantic_Type |
Pharmacologic Substance |
| UMLS_CUI |
C0085048 |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.bioontology.org/ontology/MESH/C065499 | Medical Subject Headings | LOOM |