Botulinum Toxin Type A

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82623

Treatment of cervical dystonia, severe primary axillary hyperhidrosis, Glabellar lines, blepharospasm, strabismus

A drug used to treat certain medical conditions. These include severe underarm sweating and severe muscle spasms in the neck and shoulders. OnabotulinumtoxinA is also used to smooth wrinkles on the face. It is being studied in the treatment of pain in patients with skin leiomyomas (benign smooth muscle tumors) and other conditions. It is a form of a toxin made by the bacterium Clostridium botulinum..

A toxin made by the bacterium Clostridium botulinum. It can cause food poisoning. The drug Botox is a form of the toxin that can be used in small amounts to treat certain medical conditions. These include severe underarm sweating and severe muscle spasms in the neck and shoulders. Botulinum toxin type A is also used to smooth wrinkles on the face. It is being studied in the treatment of pain in patients with skin leiomyomas (benign smooth muscle tumors) and other conditions.

93384-43-1

C82623

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

CTRP

FDA

An injectable formulation of a neurotoxin derived through the fermentation of the Hall strain of Clostridium botulinum type A with neuromuscular transmission inhibitory and analgesic activities. Upon injection into the affected muscle, the heavy chain portion of botulinum toxin type A (BTX-A) binds to the cell membrane of the motor nerve and is internalized via endocytosis. Upon entry, the light chain portion of the toxin is activated and cleaves the protein SNAP-25, thereby preventing the fusion of acetylcholine (ACh)-containing synaptic vesicles with the cell membrane and, so, the release of ACh into the neuromuscular junction; subsequent binding of ACH to motor end-plate nicotinic acid receptors and ACh-mediated muscle contraction are thus blocked. In addition to ACh, BTX-A may inhibit the release of neuropeptides, such as substance P and glutamate, which may contribute to its analgesic activity.

Botulinum Toxin Type A

E211KPY694

AbobotulinumtoxinA

Botulinum Neurotoxin Type A

Dysport

Xeomin

Botox Cosmetic

Botulinum Toxin A

BTX-A

IncobotulinumtoxinA

Onaclostox

Botulinum A Toxin

OnabotulinumtoxinA

Botox

EvabotulinumtoxinA

Botulinum Toxin Type A

Botulinum_Toxin_Type_A

634923

634923

Botulinum Toxin Type A

C82623

Botulinum Toxin Type A

Pharmacologic Substance

Amino Acid, Peptide, or Protein

C0006050

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C296