loading...| Preferred Name |
Prothrombin |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82854 |
| code |
C82854 |
| DEFINITION |
Prothrombin (622 aa, ~70 kDa) is encoded by the human F2 gene. This protein plays a role in both coagulation and proteolysis of fibrinogen. |
| DesignNote |
Prothrombin activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. (UniProt) Prothrombin catalyzes the cleavage of Arg-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. (UniProt) Prothrombin protein can be cleaved into the following 4 chains: activation peptide fragment 1, activation peptide fragment 2, thrombin light chain, thrombin heavy chain. (UniProt) Prior to secretion, prothrombin is modified to have gamma-carboxyglutamyl residues, resulting from the carboxylation of glutamyl residues by vitamin K-dependent gamma-carboxylase. These modified residues are necessary for the calcium-dependent interaction with a negatively charged phospholipid surface, which is essential for the conversion of prothrombin to thrombin. (UniProt) |
| FULL_SYN |
EC 3.4.21.5 Coagulation Factor II Factor II |
| label |
Prothrombin |
| Legacy_Concept_Name |
Prothrombin_Gene_Product |
| NCI_META_CUI |
CL449006 |
| OMIM_Number |
176930 |
| Preferred_Name |
Prothrombin |
| prefixIRI |
C82854 |
| prefLabel |
Prothrombin |
| Semantic_Type |
Enzyme Amino Acid, Peptide, or Protein |
| Swiss_Prot |
P00734 |
| subClassOf |