Medical Subject Headings

Last uploaded: November 5, 2019
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Preferred Name

Properdin
Synonyms

Factor P, Complement
Definitions

A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It stabilizes the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb) and protects it from rapid inactivation, thus facilitating the cascade of COMPLEMENT ACTIVATION and the formation of MEMBRANE ATTACK COMPLEX. Individuals with mutation in the PFC gene exhibit properdin deficiency and have a high susceptibility to infections.
ID

http://purl.bioontology.org/ontology/MESH/D011414
altLabel

Factor P, Complement

Complement factor P

Complement Factor P
AQL

AA AD AE AG AI AN BI CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
cui

C0033452
DC

1
definition

A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It stabilizes the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb) and protects it from rapid inactivation, thus facilitating the cascade of COMPLEMENT ACTIVATION and the formation of MEMBRANE ATTACK COMPLEX. Individuals with mutation in the PFC gene exhibit properdin deficiency and have a high susceptibility to infections.
DX

19660101
Inverse of AQ

http://purl.bioontology.org/ontology/MESH/Q000032

http://purl.bioontology.org/ontology/MESH/Q000138

http://purl.bioontology.org/ontology/MESH/Q000737

http://purl.bioontology.org/ontology/MESH/Q000493

http://purl.bioontology.org/ontology/MESH/Q000145

http://purl.bioontology.org/ontology/MESH/Q000506

http://purl.bioontology.org/ontology/MESH/Q000819

http://purl.bioontology.org/ontology/MESH/Q000187

http://purl.bioontology.org/ontology/MESH/Q000096

http://purl.bioontology.org/ontology/MESH/Q000037

http://purl.bioontology.org/ontology/MESH/Q000134

http://purl.bioontology.org/ontology/MESH/Q000592

http://purl.bioontology.org/ontology/MESH/Q000528

http://purl.bioontology.org/ontology/MESH/Q000008

http://purl.bioontology.org/ontology/MESH/Q000031

http://purl.bioontology.org/ontology/MESH/Q000235

http://purl.bioontology.org/ontology/MESH/Q000648

http://purl.bioontology.org/ontology/MESH/Q000276

http://purl.bioontology.org/ontology/MESH/Q000191

http://purl.bioontology.org/ontology/MESH/Q000633

http://purl.bioontology.org/ontology/MESH/Q000652

http://purl.bioontology.org/ontology/MESH/Q000009

http://purl.bioontology.org/ontology/MESH/Q000302

http://purl.bioontology.org/ontology/MESH/Q000502

http://purl.bioontology.org/ontology/MESH/Q000494

http://purl.bioontology.org/ontology/MESH/Q000266

http://purl.bioontology.org/ontology/MESH/Q000600

http://purl.bioontology.org/ontology/MESH/Q000378

http://purl.bioontology.org/ontology/MESH/Q000172

http://purl.bioontology.org/ontology/MESH/Q000627
Inverse of RB

11016-39-0
Inverse of SIB

http://purl.bioontology.org/ontology/MESH/D003176

http://purl.bioontology.org/ontology/MESH/D003186

http://purl.bioontology.org/ontology/MESH/D003166

http://purl.bioontology.org/ontology/MESH/D003183

http://purl.bioontology.org/ontology/MESH/D015938

http://purl.bioontology.org/ontology/MESH/D011415

http://purl.bioontology.org/ontology/MESH/D006466

http://purl.bioontology.org/ontology/MESH/D010958

http://purl.bioontology.org/ontology/MESH/D003175

http://purl.bioontology.org/ontology/MESH/D003185

http://purl.bioontology.org/ontology/MESH/D003172

http://purl.bioontology.org/ontology/MESH/D003182

http://purl.bioontology.org/ontology/MESH/D014168

http://purl.bioontology.org/ontology/MESH/D001613

http://purl.bioontology.org/ontology/MESH/D017242

http://purl.bioontology.org/ontology/MESH/D001620

http://purl.bioontology.org/ontology/MESH/D003184

http://purl.bioontology.org/ontology/MESH/D000706

http://purl.bioontology.org/ontology/MESH/D012738

http://purl.bioontology.org/ontology/MESH/D003181

http://purl.bioontology.org/ontology/MESH/D003169
isa

http://purl.bioontology.org/ontology/MESH/D007155
Mapped from

http://purl.bioontology.org/ontology/MESH/C564076

http://purl.bioontology.org/ontology/MESH/C537241

http://purl.bioontology.org/ontology/MESH/C070993

http://purl.bioontology.org/ontology/MESH/C564075

http://purl.bioontology.org/ontology/MESH/C000603977
MDA

19990101
MMR

20150623
MN

D12.776.124.790.223.624

D12.776.377.715.182.624

D12.776.124.486.274.965
notation

D011414
PA

D007155
prefLabel

Properdin
TERMUI

T033683

T033682
TH

NLM (1966)

NLM (1999)
tui

T116

T129
subClassOf

http://purl.bioontology.org/ontology/MESH/D003165

http://purl.bioontology.org/ontology/MESH/D001609
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Delete Mapping To Ontology Source
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118199 National Cancer Institute Thesaurus LOOM
http://purl.bioontology.org/ontology/LNC/MTHU020463 Logical Observation Identifier Names and Codes CUI
http://purl.obolibrary.org/obo/PR_000005387 Protein Ontology LOOM
http://purl.bioontology.org/ontology/LNC/LP16392-0 Logical Observation Identifier Names and Codes CUI