National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Endothelial PAS Domain-Containing Protein 1

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104306

code

C104306

DEFINITION

Endothelial PAS domain-containing protein 1 (870 aa, ~96 kDa) is encoded by the human EPAS1 gene. This protein plays a role in both the response to hypoxia and transcriptional regulation.

DesignNote

Endothelial PAS domain-containing protein 1 binds to the DNA sequence 5'-[AG]CGTG-3' found within the hypoxia response element (HRE). (UniProt)

FULL_SYN

HIF-1-Alpha-Like Factor

Hypoxia-Inducible Factor 2-Alpha

Hypoxia-Inducible Factor 2 Alpha

HIF-1 Alpha-Like Factor

Class E Basic Helix-Loop-Helix Protein 73

EPAS1

PAS Domain-Containing Protein 2

EPAS-1

Member of PAS Protein 2

HIF-2-Alpha

HIF2-Alpha

HIF-1alpha-Like Factor

bHLHe73

HLF

Basic-Helix-Loop-Helix-PAS Protein MOP2

label

Endothelial PAS Domain-Containing Protein 1

OMIM_Number

603349

Preferred_Name

Endothelial PAS Domain-Containing Protein 1

prefixIRI

C104306

prefLabel

Endothelial PAS Domain-Containing Protein 1

Semantic_Type

Amino Acid, Peptide, or Protein

Swiss_Prot

Q99814

UMLS_CUI

C1436532

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17207

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http://purl.bioontology.org/ontology/MESH/C105713 Medical Subject Headings LOOM
http://purl.obolibrary.org/obo/PR_000007106 Protein Ontology LOOM