National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Ribozyme

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1292

ALT_DEFINITION

catalytic macromolecules, frequently autohydrolytic, composed of RNA.

RNA that contains an intron sequence which has an enzyme-like catalytic activity. This intron sequence can function like an enzyme in reactions with other RNA molecules and thus synthesize new molecules even in the absence of protein.

code

C1292

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66830

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61410

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C111114

Contributing_Source

CDISC

DEFINITION

RNA that contains an intron sequence which has an enzyme-like catalytic activity. This intron sequence has been shown to fold up to form a complex surface that can function like an enzyme in reactions with other RNA molecules and thus synthesize new molecules even in the absence of protein. Synthetic ribozymes can be engineered to specifically cleave a target RNA sequence causing expression down regulation.

FULL_SYN

Ribonucleic Enzyme

RNA, Catalytic

Catalytic RNA

label

Ribozyme

Legacy_Concept_Name

Ribozyme

Preferred_Name

Ribozyme

prefixIRI

C1292

prefLabel

Ribozyme

Semantic_Type

Enzyme

Nucleic Acid, Nucleoside, or Nucleotide

UMLS_CUI

C0080125

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26549

Delete Subject Author Type Created
No notes to display
Create New Mapping

Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/SO_0000374 MicroRNA Ontology LOOM
http://purl.obolibrary.org/obo/SO_0000374 Sequence Types and Features Ontology LOOM