loading...| Preferred Name |
TATA-Box-Binding Protein |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17578 |
| code |
C17578 |
| DEFINITION |
TATA-box-binding protein (339 aa, ~38 kDa) is encoded by the human TBP gene. This protein is involved in both DNA binding and gene transcription initiation. |
| DesignNote |
The poly-Gln region of TATA-box-binding protein (amino acids 55-95 in the cannonical protein sequence) is highly polymorphic. There are 25 to 42 repeats in normal individuals and 47-63 repeats in patients with spinocerebellar ataxia 17. The TATA Binding Protein (TBP) is a DNA-binding component of the TFIID basal transcription factor of the class II genes (transcribed by RNA polymerase II), the TFIIIB class III transcription factor, and the TIF-1B (SL1) class I factor. Its name is derived from the A-T rich DNA motif that it binds to in the class II genes, most commonly TATAAAA. |
| FULL_SYN |
GTF2D TATA-Binding Protein TBP TATA-Box Factor TATA Box Binding Protein Transcription Initiation Factor TFIID TBP Subunit TATA-Binding Factor TATA Sequence-Binding Protein TATA Box-Binding Protein GTF2D1 SCA17 |
| label |
TATA-Box-Binding Protein |
| Legacy_Concept_Name |
TATA_Box_Binding_Protein |
| OMIM_Number |
600075 |
| Preferred_Name |
TATA-Box-Binding Protein |
| prefixIRI |
C17578 |
| prefLabel |
TATA-Box-Binding Protein |
| Semantic_Type |
Biologically Active Substance Amino Acid, Peptide, or Protein |
| Swiss_Prot |
P20226 |
| UMLS_CUI |
C0144555 |
| subClassOf |