Tumor Necrosis Factor Receptor Superfamily Member 10A

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18174

A protein on the surface of certain cells that binds another protein called TRAIL, which may kill some cancer cells. An increase in the amount or activity of death receptor 4 on cancer cells may kill more cells.

C18174

Tumor necrosis factor receptor superfamily member 10A (468 aa, 50 kD) is a cell fate protein that is encoded by the human TNFRSF10A gene and may have roles in induction of apoptosis.

A member of the TNF family. TRAIL Receptor 1 (DR4) contains two cysteine-rich pseudorepeats resembling regions in TNFR1, DR3, and FAS, a transmembrane domain, and an intracellular death domain. Unlike FAS, TNFR1, and DR3, DR4 does not use FADD to transmit the death signal, suggesting the use of a distinct signaling machinery.

TNFRSF10A

Death Receptor 4

TRAIL-R1

Cytotoxic TRAIL Receptor

TRAIL Receptor 1

TNF-Related Apoptosis Inducing Ligand Receptor 1

Tumor Necrosis Factor Receptor Superfamily Member 10A

TRAIL_Receptor-1

603611

Tumor Necrosis Factor Receptor Superfamily Member 10A

C18174

Tumor Necrosis Factor Receptor Superfamily Member 10A

Amino Acid, Peptide, or Protein

Receptor

O00220

C1504635

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C19285