XIAP-Associated Factor 1

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20929

C20929

XIAP-associated factor 1 (301 aa, ~35 kDa) is encoded by the human XAF1 gene. This protein plays a role in the regulation of apoptosis.

Widely expressed (highest in heart, ovary; lowest in brain, testis) by human XAF1 Gene (IAP Family), 317-aa 37-kDa XIAP-Associated Factor 1 contains 3 Cys-rich BIR domains (bind to and inhibit caspases), 7 zinc fingers, and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase activity. Associated with nuclear redistribution of XIAP, cytoplasmic XAF1 appears to antagonize nuclear XIAP inhibition of CASP3 activity. (NCI)

BIRC4-Binding Protein

ZAP-1

XAF1

XIAP-Associated Factor 1

XIAP-Associated_Factor-1

606717

XIAP-Associated Factor 1

C20929

XIAP-Associated Factor 1

Amino Acid, Peptide, or Protein

Q6GPH4

C1447833

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C19928