DNA-(Apurinic or Apyrimidinic Site) Lyase

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21415

C21415

DNA-(apurinic or apyrimidinic site) lyase (318 aa, ~36 kDa) is encoded by the human APEX1 gene. This protein plays a role in both DNA repair and the regulation of transcription.

A potent activator of p53 protein, APE1 may protect against cell lethality and suppress mutations produced by spontaneous hydrolysis, by chemicals and radiation, or by DNA glycosylases that remove abnormal bases from DNA. Abasic sites that can block DNA replication and cause mutations must be corrected to restore genetic integrity. A repressor of the PTH gene, APE binds to promoter negative Ca(2+)-response elements, which are also present in the APE1 gene.

AP Endonuclease 1

Deoxyribonuclease (Apurinic or Apyrimidinic)

HAP1

APEX1

AP Endonuclease Class I

EC 4.2.99.18

Multifunctional DNA Repair Enzyme

APEX Nuclease

REF-1

REF1

APEN

APX

APEX

APEX Nuclease (Multifunctional DNA Repair Enzyme)

Apurinic/Apyrimidinic Exonuclease

Redox Factor-1

APE-1

EC 3.1.-.-

APE1

APE

AP Lyase

Apurinic/Apyrimidinic Endonuclease 1

Apurinic/Apyrimidinic (Abasic) Endonuclease

DNA-(Apurinic or Apyrimidinic Site) Lyase

APEX_Nuclease

107748

DNA-(Apurinic or Apyrimidinic Site) Lyase

C21415

DNA-(Apurinic or Apyrimidinic Site) Lyase

Amino Acid, Peptide, or Protein

P27695

C0140145

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21422