National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Aminoglycoside Antibiotic

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2363

ALT_DEFINITION

A family of antibiotics that works against many types of bacteria and includes streptomycin, gentamicin, and neomycin. Aminoglycosides are used to treat bacterial infections.

CHEBI_ID

CHEBI:22507

code

C2363

DEFINITION

Any antibiotic containing amino-modified sugars originally isolated from various Streptomyces and Micromonospora species. Aminoglycoside antibiotics bind to the 16S RNA of the bacterial 30S ribosomal subunit, inhibiting translation and protein synthesis. Aminoglycoside use is associated with ototoxicity, neurotxicity and nephrotoxicity.

FULL_SYN

Aminoglycosides

Aminoglycoside Agents

Aminoglycoside Drugs

label

Aminoglycoside Antibiotic

Legacy_Concept_Name

Aminoglycoside_Antibiotic

Preferred_Name

Aminoglycoside Antibiotic

prefixIRI

C2363

prefLabel

Aminoglycoside Antibiotic

Semantic_Type

Chemical Viewed Functionally

UMLS_CUI

C0002556

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C258

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C784

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http://purl.obolibrary.org/obo/CHEBI_22507 Chemical Entities of Biological Interest Ontology LOOM
http://purl.obolibrary.org/obo/CHEBI_22507 International Classification of Diseases Ontology LOOM
http://purl.obolibrary.org/obo/CHEBI_22507 GenEpiO LOOM