National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Vasopressin V1B Receptor

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26097

code

C26097

DEFINITION

Vasopressin V1b receptor (424 aa, ~47 kDa) is encoded by the human AVPR1B gene. This protein plays a role in G protein-coupled receptor signaling mediated by vasopressin.

DesignNote

This protein acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known.

FULL_SYN

V1bR

AVPR V3

AVPR1B

AVPR V1b

Arginine Vasopressin Receptor 3

Arginine Vasopressin Receptor 1B

Antidiuretic Hormone Receptor 1B

Pituitary Vasopressin Receptor 3

label

Vasopressin V1B Receptor

Legacy_Concept_Name

Arginine_Vasopressin_Receptor-1B

OMIM_Number

600264

Preferred_Name

Vasopressin V1B Receptor

prefixIRI

C26097

prefLabel

Vasopressin V1B Receptor

Semantic_Type

Amino Acid, Peptide, or Protein

Receptor

Swiss_Prot

P47901

UMLS_CUI

C0284726

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17345

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http://purl.obolibrary.org/obo/PR_000001682 Protein Ontology LOOM