Zinc Finger Protein Gfi-1b

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26384

C26384

Zinc finger protein Gfi-1b (330 aa, ~37 kDa) is encoded by the human GFI1B gene. This protein is involved in both transcriptional regulation and cell proliferation.

Growth Factor Independence-1B, encoded by the human GFI1B gene, is a zinc finger protein. This protein is a transcription factor with specific involvement in the regulation of erythroid cell growth in normal erythropoiesis through modulating erythroid-specific gene expression. The function of GFI1B to modulate transcription depends on promoter context. Human GFI1B expression by Northern blot analysis is highest in bone marrow and fetal liver as well as in the chronic myeloid leukemia cell line K562 with lower levels in other hematopoietic precursor cells. Expression of GFI1B is highly restricted to hematopoietic stem cells, erythroblasts, and megakaryocytes. Its expression does not promote erythroid commitment, but enhances proliferation of immature erythroblasts. The chromosomal region of this gene is translocated to chromosome 22q11 in chronic myeloid leukemia. (OMIM, PubMed 12351384)

Potential Regulator of CDKN1A Translocated in CML

GF11B Protein

GFI1B

Growth Factor Independent Protein 1B

Growth Factor Independence-1B

Zinc Finger Protein Gfi-1b

Growth_Factor_Independence-1B_Protein

604383

Zinc Finger Protein Gfi-1b

C26384

Zinc Finger Protein Gfi-1b

Biologically Active Substance

Amino Acid, Peptide, or Protein

Q5VTD9

C1333880

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17207