National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Histone Deacetylation

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C40580

code

C40580

DEFINITION

Histone Deacetylation is the covalent post-translational enzymatic addition of an acetyl group(s) to a histone protein. By exposing cationic sites on the protein that promote ionic interaction with the negatively charged DNA backbone, Histone Deacetylation induces DNA condensation and regulates genetic functions, such as transcription. (NCI)

label

Histone Deacetylation

Legacy_Concept_Name

Histone_Deacetylation

Preferred_Name

Histone Deacetylation

prefixIRI

C40580

prefLabel

Histone Deacetylation

Semantic_Type

Physiologic Function

UMLS_CUI

C1156201

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17019

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http://purl.obolibrary.org/obo/GO_0016575 Gene Ontology LOOM