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loading...| Preferred Name |
Ciglitazone |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C72726 |
| CAS_Registry |
74772-77-3 |
| CHEBI_ID |
CHEBI:64227 |
| Chemical_Formula |
C18H23NO3S |
| code |
C72726 |
| Concept_In_Subset | |
| Contributing_Source |
FDA |
| DEFINITION |
An agent belonging to the glitazone (thiazolidinedione) class of antidiabetic agents with antihyperglycemic activity. Ciglitazone also exerts anti-inflammatory activity through the modulation of nuclear factor-kappaB-mediated pathways. In addition, this agent inhibits angiogenesis by reducing vascular endothelial growth factor (VEGF) production and inhibits growth of melanoma cells by inhibiting the expression of (C-X-C motif) ligand 1 (CXCL1). This agent is the prototypical compound for the thiazolidinedione class, and has never been marketed. |
| FDA_UNII_Code |
U8QXS1WU8G |
| label |
Ciglitazone |
| Legacy_Concept_Name |
Ciglitazone |
| Preferred_Name |
Ciglitazone |
| prefixIRI |
C72726 |
| prefLabel |
Ciglitazone |
| Semantic_Type |
Pharmacologic Substance |
| UMLS_CUI |
C0055721 |
| subClassOf |
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| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.obolibrary.org/obo/CHEBI_64227 | Chemical Entities of Biological Interest Ontology | LOOM | |
| http://purl.bioontology.org/ontology/MESH/C039671 | Medical Subject Headings | LOOM |