National Cancer Institute Thesaurus

Last uploaded: February 21, 2019

Preferred Name	Apatinib
ID	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C74012
code	C74012
Concept_In_Subset	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978
Contributing_Source	CTRP
DEFINITION	An orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. Apatinib selectively binds to and inhibits vascular endothelial growth factor receptor 2, which may inhibit VEGF-stimulated endothelial cell migration and proliferation and decrease tumor microvessel density. In addition, this agent mildly inhibits c-Kit and c-SRC tyrosine kinases.
Display_Name	Apatinib
FULL_SYN	YN968D1
label	Apatinib
Legacy_Concept_Name	Apatinib
PDQ_Closed_Trial_Search_ID	592508
PDQ_Open_Trial_Search_ID	592508
Preferred_Name	Apatinib
prefixIRI	C74012
prefLabel	Apatinib
Semantic_Type	Pharmacologic Substance
UMLS_CUI	C2346836
subClassOf	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1967

Delete	Subject	Author	Type	Created
No notes to display

Delete	Mapping To	Ontology	Source
	http://purl.bioontology.org/ontology/MESH/C553458	Medical Subject Headings	LOOM