National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Ulipristal Acetate

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91057

CAS_Registry

126784-99-4

Chemical_Formula

C30H37NO4

code

C91057

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

An orally bioavailable, acetate salt of ulipristal, a selective progesterone receptor modulator with anti-progesterone activity. Ulipristal binds to the progesterone receptor (PR), thereby inhibiting PR-mediated gene expression, and interfering with progesterone activity in the reproductive system. As a result, this agent may suppress the growth of uterine leiomyomatosis. Furthermore, by inhibiting or delaying ovulation and effecting endometrial tissue, ulipristal can be used as an emergency contraception

FDA_UNII_Code

YF7V70N02B

FULL_SYN

Ella

VA-2914

PGL-4001

RTI-3021-012

17-alpha-acetoxy-11-beta-(4-dimethylaminophenyl)-19-norpregna-4,9-dien-3,20-dione

11-beta-17-(acetyloxy)-11-(4-(dimethylamino)phenyl)-19-norpregna-4,9-diene-3,20-dione

CDB-2914

label

Ulipristal Acetate

PDQ_Closed_Trial_Search_ID

729448

PDQ_Open_Trial_Search_ID

729448

Preferred_Name

Ulipristal Acetate

prefixIRI

C91057

prefLabel

Ulipristal Acetate

PubMedID_Primary_Reference

22296076

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C2723461

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1891

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http://purl.obolibrary.org/obo/CHEBI_71025 Chemical Entities of Biological Interest Ontology LOOM
http://purl.bioontology.org/ontology/MESH/C555622 Medical Subject Headings LOOM