Chronic Myeloid Leukemia Pathway

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91465

Chronic myelogenous leukaemia (CML) is a biphasic disease, initiated by expression of the BCR/ABL fusion gene product in self-renewing, haematopoietic stem cells (HSCs). HSCs can differentiate into common myeloid progenitors (CMPs), which then differentiate into granulocyte/macrophage progenitors (GMPs). HSCs can also differentiate into common lymphoid progenitors (CLPs), which are the progenitors of lymphocytes such as T cells and B cells. The initial chronic phase of CML (CML-CP) is characterized by a massive expansion of the granulocytic-cell series. Acquisition of additional genetic mutations beyond expression of BCR/ABL causes the progression of CML from chronic phase to blast phase (CML-BP), characterized by an accumulation of myeloid or lymphoid blast cells.

C91465

Chronic myeloid leukemia

CML Pathway

hsa05220

Chronic Myeloid Leukemia Pathway

Chronic Myeloid Leukemia Pathway

C91465

Chronic Myeloid Leukemia Pathway

Functional Concept

C2984277

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91436