Graft-Versus-Host Disease Pathway

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91481

Graft-versus-host disease (GVHD) pathophysiology can be summerized in a three-step process. During step 1, the conditioning regimen (irradiation and/or chemotherapy) leads to damage, activation of host tissues and induction of inflammatory cytokines [tumour necrosis factor (TNF-alpha) and interleukin (IL-1)] secretion. Increased expression of major histocompatibility complex (MHC) antigens and adhesion molecules leads to enhancement of the recognition of host MHC and/or minor histocompatibility antigens by mature donor T cells.

C91481

GVHD Pathway

Graft-versus-host disease

hsa05332

Graft-Versus-Host Disease Pathway

Graft-Versus-Host Disease Pathway

C91481

Graft-Versus-Host Disease Pathway

Functional Concept

C2984293

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39701