Systemic Lupus Erythematosus Pathway

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91508

Systemic lupus erythematosus (SLE) is characterized by circulating IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and certain cytoplasmic components. Immune complexes comprising autoantibody and self-antigen is deposited particularly in the renal glomeruli and mediate a systemic inflammatory response by activating complement or via Fc-gamma-R-mediated neutrophil and macrophage activation. Activation of complement leads to injury both through formation of the membrane attack complex (C5b-9) or by generation of the anaphylatoxin and cell activator C5a. Neutrophils and macrophages cause tissue injury by the release of oxidants and proteases.

C91508

SLE Pathway

Systemic lupus erythematosus

hsa05322

Systemic Lupus Erythematosus Pathway

Systemic Lupus Erythematosus Pathway

C91508

Systemic Lupus Erythematosus Pathway

Functional Concept

C2984317

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39701