loading...| Preferred Name |
T cell receptor signaling pathway |
| Synonyms |
TCR signaling pathway TCR signaling |
| Definitions |
T cell receptor (TCR) signaling in developing thymocytes is important for the establishment of CD4 and CD8 lineages. Mature T cells express either CD4 or CD8 co-receptors which are essential for the interaction with peptide-bound class II or class I MHC complexes to elicit CD4 T helper (Th) or CD8 cytotoxic T lymphocyte responses, respectively. In either case, T cell-initiated signaling activates the expression of genes whose products mediate these responses. |
| ID |
http://purl.obolibrary.org/obo/PW_0000821 |
| created_by |
VPetri |
| creation_date |
2010-10-27T03:28:43Z |
| definition |
T cell receptor (TCR) signaling in developing thymocytes is important for the establishment of CD4 and CD8 lineages. Mature T cells express either CD4 or CD8 co-receptors which are essential for the interaction with peptide-bound class II or class I MHC complexes to elicit CD4 T helper (Th) or CD8 cytotoxic T lymphocyte responses, respectively. In either case, T cell-initiated signaling activates the expression of genes whose products mediate these responses. |
| has_alternative_id |
KEGG:04660 Reactome:R-HSA-202403 GO:0050852 |
| has_obo_namespace |
pathway |
| has_related_synonym |
TCR signaling pathway TCR signaling |
| id |
PW:0000821 |
| label |
T cell receptor signaling pathway |
| notation |
PW:0000821 |
| part_of | |
| prefLabel |
T cell receptor signaling pathway |
| treeView | |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.obolibrary.org/obo/GO_0050852 | Gene Ontology | LOOM |