loading...| Preferred Name |
mast cell |
| Synonyms |
histaminocyte |
| Definitions |
在几乎所有含有大量嗜碱性颗粒的组织中发现的一种细胞，能在激活时能够释放大量的组胺和肝素。祖细胞离开骨髓并在结缔组织和粘膜组织中成熟。除了血流以外，所有的组织都有成熟的肥大细胞。他们的表型是CD117高表达，CD123阴性，CD193阳性，CD200R3阳性和FceRI高表达。干细胞因子（KIT-ligand； SCF）是其生存和发展的主要控制信号。 肥大细胞通常是整合素β-7阴性，并且对TLR2，TLR3，TLR4，TLR5，TLR7，TLR9，C3aR，C5aR，CR3，CR4，VEGF，FGF2和肾素呈阳性。它们可以在表面上表达MHC I类和II类。活化的鼠肥大细胞（IgE +抗原）能够表达以下协同刺激分子：CD95（Fas），CD120b，CD137（4-1BB），CD153（CD30L），CD154（CD40L），GITR，ICOSL，OX40L， PD-L1和PD-L2。请注意，有一些小鼠应变的变化。肥大细胞也已被证明产生bFGF，CCL2，CCL4，CCL5，CCL11，CCL20，CXCL2，CXCL8、CXCL10、GM-CSF、IFN-γ、IL-1、IL-2、IL-3、IL-8、IL-10、IL-11、IL-12、IL-13、IL-16、IL-25、IL-18、MIP-1、前列腺素D2、SCF、TGF-β、TNF-α、TSLP和XCL1。它们表达转录因子AP-1，GATA1，MITF，Notch2，PIAS3，PU.1和STAT5。 Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5. |
| ID |
http://purl.obolibrary.org/obo/CL_0000097 |
| comment |
肥大细胞通常是整合素β-7阴性，并且对TLR2，TLR3，TLR4，TLR5，TLR7，TLR9，C3aR，C5aR，CR3，CR4，VEGF，FGF2和肾素呈阳性。它们可以在表面上表达MHC I类和II类。活化的鼠肥大细胞（IgE +抗原）能够表达以下协同刺激分子：CD95（Fas），CD120b，CD137（4-1BB），CD153（CD30L），CD154（CD40L），GITR，ICOSL，OX40L， PD-L1和PD-L2。请注意，有一些小鼠应变的变化。肥大细胞也已被证明产生bFGF，CCL2，CCL4，CCL5，CCL11，CCL20，CXCL2，CXCL8、CXCL10、GM-CSF、IFN-γ、IL-1、IL-2、IL-3、IL-8、IL-10、IL-11、IL-12、IL-13、IL-16、IL-25、IL-18、MIP-1、前列腺素D2、SCF、TGF-β、TNF-α、TSLP和XCL1。它们表达转录因子AP-1，GATA1，MITF，Notch2，PIAS3，PU.1和STAT5。 Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5. |
| capable of |
http://purl.obolibrary.org/obo/GO_0002539 http://purl.obolibrary.org/obo/GO_0002690 http://purl.obolibrary.org/obo/GO_0002349 http://purl.obolibrary.org/obo/GO_0002830 |
| database_cross_reference |
BTO:0000830 CALOHA:TS-0603 FMA:66784 |
| develops_from | |
| has plasma membrane part | |
| has_high_plasma_membrane_amount | |
| label |
肥大细胞 mast cell |
| lacks_plasma_membrane_part | |
| prefixIRI |
CL:0000097 |
| prefLabel |
mast cell |
| textual definition |
在几乎所有含有大量嗜碱性颗粒的组织中发现的一种细胞，能在激活时能够释放大量的组胺和肝素。祖细胞离开骨髓并在结缔组织和粘膜组织中成熟。除了血流以外，所有的组织都有成熟的肥大细胞。他们的表型是CD117高表达，CD123阴性，CD193阳性，CD200R3阳性和FceRI高表达。干细胞因子（KIT-ligand； SCF）是其生存和发展的主要控制信号。 A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development. |
| treeView | |
| 引自 | |
| 有_obo_命名空间 |
细胞 cell |
| 有_相关的_同义词 |
tissue basophil 组织嗜碱性粒细胞 |
| 有_精确的_同义词 |
histaminocyte 肥大细胞(mastocyte) 肥大细胞(labrocyte) mastocyte labrocyte |
| has_part | |
| subClassOf |