loading...| Preferred Name |
interleukin-17 |
| Synonyms |
IL17 fam:IL-17 |
| Definitions |
Category=family. A protein that is a T cell-derived cytokine that may play an important role in the initiation or maintenance of the proinflammatory response. Except for IL-17B, all other IL-17 family members are homodimers containing five highly conserved cysteine residues forming characteristic cystein-knot structure, similar to that found in the TGF-beta-like cystine-knot (PR:000000008). This class consists of six cytokines. Among them, interleukin 17A (IL-17) and IL-17F are expressed by a novel subset of CD4+ helper T (Th) cells and play a critical role in inflammation and autoimmunity. On the other hand, IL-17E, also called IL-25, has been associated with allergic responses. |
| ID |
http://purl.obolibrary.org/obo/PR_000001092 |
| comment |
Category=family. |
| database_cross_reference |
PIRSF:PIRSF003430 PANTHER:PTHR21295 |
| definition |
A protein that is a T cell-derived cytokine that may play an important role in the initiation or maintenance of the proinflammatory response. Except for IL-17B, all other IL-17 family members are homodimers containing five highly conserved cysteine residues forming characteristic cystein-knot structure, similar to that found in the TGF-beta-like cystine-knot (PR:000000008). This class consists of six cytokines. Among them, interleukin 17A (IL-17) and IL-17F are expressed by a novel subset of CD4+ helper T (Th) cells and play a critical role in inflammation and autoimmunity. On the other hand, IL-17E, also called IL-25, has been associated with allergic responses. |
| has_exact_synonym |
IL17 fam:IL-17 |
| has_obo_namespace |
protein |
| id |
PR:000001092 |
| label |
interleukin-17 |
| notation |
PR:000001092 |
| prefLabel |
interleukin-17 |
| subClassOf |