loading...| Preferred Name |
negative regulation of gene expression |
| Definitions |
This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation. Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. |
| ID |
http://purl.obolibrary.org/obo/GO_0010629 |
| comment |
This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation. |
| has participant |
http://purl.obolibrary.org/obo/PR_P03372 http://purl.obolibrary.org/obo/PR_P01375 http://purl.obolibrary.org/obo/PR_P06401 http://purl.obolibrary.org/obo/PR_P36507 http://purl.obolibrary.org/obo/PR_P06241 |
| has_obo_namespace |
biological_process |
| id |
GO:0010629 |
| imported from | |
| label |
negative regulation of gene expression |
| notation |
GO:0010629 |
| prefLabel |
negative regulation of gene expression |
| textual definition |
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. |
| subClassOf |