A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.
ID
http://purl.bioontology.org/ontology/MESH/D014841
altLabel
Factor VIIIR-RCo
Factor VIII-Related Antigen
Factor VIIIR Ag
Ristocetin Cofactor
Plasma Factor VIII Complex
Factor VIIIR-Ag
Factor VIII Related Antigen
Ristocetin Willebrand Factor
Ristocetin-Willebrand Factor
von Willebrand Protein
Factor VIIIR RCo
AN
/ defic = VON WILLEBRAND DISEASE or specific type of Von Willebrand Disease
AQL
AA AD AE AG AI AN BI CF CH CL CS DE EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
cui
C0042971
C0032114
DC
1
definition
A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.
DX
19860101
FX
D056728
D020302
D056725
D056729
D014842
D003029
HN
86(76); was see under BLOOD COAGULATION FACTORS 1976-85; FACTOR VIII RELATED ANTIGEN, previously in the Supplementary Chemical File, was mapped to both FACTOR VIII & ANTIGENS 1977-89
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