National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Antithrombin-III

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104683

code

C104683

DEFINITION

Antithrombin-III (464 aa, ~53 kDa) is encoded by the human SERPINC1 gene. This protein is involved in the negative regulation of serine proteinase activity during blood coagulation.

DesignNote

Antithrombin-III can inhibit thrombin, matriptase-3/TMPRSS7, and coagulation factors IXa, Xa and Xia. (UniProt)

FULL_SYN

SERPINC1

Serpin C1

Antithrombin III

ATIII

Serine-Cysteine Proteinase Inhibitor Clade C Member 1

label

Antithrombin-III

NCI_META_CUI

CL360008

OMIM_Number

107300

Preferred_Name

Antithrombin-III

prefixIRI

C104683

prefLabel

Antithrombin-III

Semantic_Type

Amino Acid, Peptide, or Protein

Swiss_Prot

P01008

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17122

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http://purl.obolibrary.org/obo/PR_000003252 Human Phenotype Ontology China LOOM
http://purl.obolibrary.org/obo/PR_000003252 Protein Ontology LOOM
http://purl.obolibrary.org/obo/PR_000003252 Ontology for Biomedical Investigations LOOM
http://purl.bioontology.org/ontology/MESH/D000990 Medical Subject Headings LOOM