National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Microtubule

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C13256

ALT_DEFINITION

Slender, cylindrical filaments found in the cytoskeleton of plant and animal cells. They are composed of the protein TUBULIN.

code

C13256

DEFINITION

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. (from LocusLink)

FULL_SYN

Micro Tubule

Micro-tubule

label

Microtubule

Legacy_Concept_Name

Microtubule

Preferred_Name

Microtubule

prefixIRI

C13256

prefLabel

Microtubule

Semantic_Type

Cell Component

UMLS_CUI

C0026046

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C32603

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http://purl.obolibrary.org/obo/GO_0005874 Human Phenotype Ontology China LOOM
http://purl.obolibrary.org/obo/GO_0005874 Phenotypic Quality Ontology LOOM
http://purl.obolibrary.org/obo/GO_0005874 Cell Ontology LOOM
http://purl.obolibrary.org/obo/GO_0005874 Gene Ontology LOOM
http://purl.obolibrary.org/obo/FMA_63849 Foundational Model of Anatomy LOOM