loading...| Preferred Name |
T-Cell Differentiation |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C19055 |
| code |
C19055 |
| DEFINITION |
Development of bone marrow-derived stem cells in the thymus through stages of positive selection under the influence of epithelial cells in the thymic cortex and negative selection under the influence of bone marrow-derived dendritic cells at the corticomedullary junction. Thymic T cell precursors (thymocytes) progress through phases expressing both CD4 and CD8 coreceptors to a single positive stage expressing only CD4 or CD8 in addition to the T cell receptor. They are then allowed to leave the thymus and enter the periphery via the lymphatics or venules of the circulatory system as mature T cells. (NCI/OSP) |
| FULL_SYN |
T-Cell Development T-Cell Ontogeny T-Lymphocyte Development |
| label |
T-Cell Differentiation |
| Legacy_Concept_Name |
T-Cell_Development |
| Preferred_Name |
T-Cell Differentiation |
| prefixIRI |
C19055 |
| prefLabel |
T-Cell Differentiation |
| Semantic_Type |
Cell Function |
| UMLS_CUI |
C1155013 |
| subClassOf |