National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

V(D)J Recombination

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20971

code

C20971

DEFINITION

Any process of gene rearrangement in which the original variable and joining region coding segments of the immunoglobulin and T cell receptor genes are ligated to create a novel protein-coding capacity. This process may occur with inclusion of the diversity coding segment to create a V(D)J coding gene. V(D)J recombination is involved in generation of diversity for both antibody and T cell receptor responses.

FULL_SYN

V(D)J Rearrangement

Immunoglobulin V(D)J Rearrangement

label

V(D)J Recombination

Legacy_Concept_Name

V-D-J_Recombination

Preferred_Name

V(D)J Recombination

prefixIRI

C20971

prefLabel

V(D)J Recombination

Semantic_Type

Genetic Function

UMLS_CUI

C1519877

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20045

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http://purl.bioontology.org/ontology/MESH/D060152 Medical Subject Headings LOOM
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http://purl.obolibrary.org/obo/GO_0033151 Cell Ontology LOOM
http://purl.obolibrary.org/obo/GO_0033151 Cell Line Ontology Subset for Chinese National Infrastructure of Cell Line Resource (NICR) LOOM
http://purl.obolibrary.org/obo/GO_0033151 Gene Ontology LOOM