National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Cholesterol

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C369

ALT_DEFINITION

A waxy, fat-like substance made in the liver, and found in the blood and in all cells of the body. Cholesterol is important for good health and is needed for making cell walls, tissues, hormones, vitamin D, and bile acid. Cholesterol also comes from eating foods taken from animals such as egg yolks, meat, and whole-milk dairy products. Too much cholesterol in the blood may build up in blood vessel walls, block blood flow to tissues and organs, and increase the risk of developing heart disease and stroke.

Lipid composed of 27 carbon atoms which form three fused cycloheane (6-carbon) rings, a cyclopentane (5-carbon ring) and a side chain of 8 carbon atoms. (Ensminger et al).

CAS_Registry

57-88-5

CHEBI_ID

CHEBI:16113

Chemical_Formula

C27H46O

code

C369

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

CRCH

FDA

DEFINITION

An animal sterol found in the body tissues (and blood plasma) of vertebrates. It can be found in large concentrations within the liver, spinal cord, and brain. Cholesterol is an important component of the membranes of cells, providing stability. It is the major precursor for the synthesis of vitamin D, of the various steroid hormones, including cortisol, cortisone, and aldosterone in the adrenal glands, and of the sex hormones progesterone, estrogen, and testosterone. Cholesterol also has an important role for the brain synapses as well as in the immune system. In conditions featuring elevated low density lipoproteins (LDL), cholesterol often forms plaque deposits in the walls of arteries, a condition known as atherosclerosis, which is a major contributor to coronary heart disease and other forms of cardiovascular disease.

FDA_UNII_Code

97C5T2UQ7J

FULL_SYN

(-)-Cholesterol

(3beta)-Cholest-5-en-3-ol

5-cholesten-3B-ol

INFOODS

CHOLE

label

Cholesterol

Legacy_Concept_Name

Cholesterol

NSC_Code

8798

Preferred_Name

Cholesterol

prefixIRI

C369

prefLabel

Cholesterol

Semantic_Type

Organic Chemical

UMLS_CUI

C0008377

Unit

mg

US_Recommended_Intake

Y

USDA_ID

601

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C68342

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http://purl.bioontology.org/ontology/LNC/LP15493-7 Logical Observation Identifier Names and Codes LOOM
http://purl.bioontology.org/ontology/MESH/D002784 Medical Subject Headings LOOM
http://purl.bioontology.org/ontology/LNC/LP100019-1 Logical Observation Identifier Names and Codes LOOM
http://purl.bioontology.org/ontology/MEDLINEPLUS/C0008377 MedlinePlus Health Topics LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003147 Logical Observation Identifier Names and Codes LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 Chemical Entities of Biological Interest Ontology LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 Human Phenotype Ontology China LOOM