National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Folic Acid

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C510

ALT_DEFINITION

Synthetic folate in fortified foods and supplements containing a single glutamate molecule.

A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Folate helps to make red blood cells. It is found in whole-grain breads and cereals, liver, green vegetables, orange juice, lentils, beans, and yeast. Folate is water-soluble (can dissolve in water) and must be taken in every day. Not enough folate can cause anemia (a condition in which the number of red blood cells is below normal), diseases of the heart and blood vessels, and defects in the brain and spinal cord in a fetus. Folate is being studied with vitamin B12 in the prevention and treatment of cancer.

CAS_Registry

59-30-3

CHEBI_ID

CHEBI:27470

Chemical_Formula

C19H19N7O6

code

C510

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

CRCH

FDA

DEFINITION

A collective term for pteroylglutamic acids and their oligoglutamic acid conjugates. As a natural water-soluble substance, folic acid is involved in carbon transfer reactions of amino acid metabolism, in addition to purine and pyrimidine synthesis, and is essential for hematopoiesis and red blood cell production. (NCI05)

Display_Name

Folic Acid

FDA_UNII_Code

935E97BOY8

FULL_SYN

Vitamin B9

Folacin

N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid

2-[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]aminopentanedioic acid

Vitamin Bc

N-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid

FA

Pteroylmonoglutamic Acid

INFOODS

FOLAC

label

Folic Acid

Legacy_Concept_Name

Folic_Acid

NSC_Code

3073

PDQ_Closed_Trial_Search_ID

39641

PDQ_Open_Trial_Search_ID

39641

Preferred_Name

Folic Acid

prefixIRI

C510

prefLabel

Folic Acid

Semantic_Type

Organic Chemical

Vitamin

Tolerable_Level

Y

UMLS_CUI

C0016410

Unit

mcg

US_Recommended_Intake

Y* (*for women of childbearing age)

USDA_ID

431

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1444

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http://purl.bioontology.org/ontology/MEDLINEPLUS/C0016410 MedlinePlus Health Topics LOOM
http://purl.bmicc.cn/ontology/ICD11CN/XM7R82 International Classification of Diseases, 11th Edition, China LOOM
http://purl.obolibrary.org/obo/CHEBI_27470 Chemical Entities of Biological Interest Ontology LOOM
http://purl.obolibrary.org/obo/CHEBI_27470 Human Phenotype Ontology China LOOM
http://purl.bioontology.org/ontology/MESH/D005492 Medical Subject Headings LOOM