loading...| Preferred Name |
Retinoblastoma |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7541 |
| ALT_DEFINITION |
Cancer that forms in the tissues of the retina (the light-sensitive layers of nerve tissue at the back of the eye). Retinoblastoma usually occurs in children younger than 5 years. It may be hereditary or nonhereditary (sporadic). A malignant tumor of the eye comprised of immature retinal cells. A malignant neoplasm originating in the nuclear layer of the retina. |
| code |
C7541 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66830 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C103061 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C88025 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61410 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118464 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C90259 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102905 |
| Contributing_Source |
CTEP CTRP CDISC NICHD MedDRA |
| DEFINITION |
A malignant tumor that originates in the nuclear layer of the retina. As the most common primary tumor of the eye in children, retinoblastoma is still relatively uncommon, accounting for only 1% of all malignant tumors in pediatric patients. Approximately 95% of cases are diagnosed before age 5. These tumors may be multifocal, bilateral, congenital, inherited, or acquired. Seventy-five percent of retinoblastomas are unilateral; 60% occur sporadically. A predisposition to retinoblastoma has been associated with 13q14 cytogenetic abnormalities. Patients with the inherited form also appear to be at increased risk for secondary nonocular malignancies such as osteosarcoma, malignant fibrous histiocytoma, and fibrosarcoma. |
| Display_Name |
Retinoblastoma |
| FULL_SYN |
RETINOBLASTOMA, MALIGNANT RB |
| Has_NICHD_Parent | |
| ICD-O-3_Code |
9510/3 |
| label |
Retinoblastoma |
| Legacy_Concept_Name |
Retinoblastoma |
| Neoplastic_Status |
Malignant |
| NICHD_Hierarchy_Term |
Retinoblastoma |
| Preferred_Name |
Retinoblastoma |
| prefixIRI |
C7541 |
| prefLabel |
Retinoblastoma |
| Semantic_Type |
Neoplastic Process |
| UMLS_CUI |
C0035335 |
| subClassOf |