National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Serotonin

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C828

ALT_DEFINITION

A hormone found in the brain, platelets, digestive tract, and pineal gland. It acts both as a neurotransmitter (a substance that nerves use to send messages to one another) and a vasoconstrictor (a substance that causes blood vessels to narrow). A lack of 5-hydroxytryptamine in the brain is thought to be a cause of depression.

A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.

CAS_Registry

50-67-9

CHEBI_ID

CHEBI:28790

Chemical_Formula

C10H12N2O

code

C828

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

FDA_UNII_Code

333DO1RDJY

FULL_SYN

5-HT

5-Hydroxytryptamine

label

Serotonin

Legacy_Concept_Name

Serotonin

NSC_Code

58241

Preferred_Name

Serotonin

prefixIRI

C828

prefLabel

Serotonin

Semantic_Type

Biologically Active Substance

Organic Chemical

UMLS_CUI

C0036751

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C687

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