National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Synapse

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C13281

ALT_DEFINITION

The space between the end of a nerve cell and another cell. Nerve impulses are usually carried to the neighboring cell by chemicals called neurotransmitters, which are released by the nerve cell and are taken up by another cell on the other side of the synapse. The neighboring cell may be another nerve cell, a muscle cell, or a gland cell.

code

C13281

DEFINITION

Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate through direct electrical connections which are sometimes called electrical synapses.

label

Synapse

Legacy_Concept_Name

Synapse

Preferred_Name

Synapse

prefixIRI

C13281

prefLabel

Synapse

Semantic_Type

Anatomical Structure

UMLS_CUI

C0039062

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C13983

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http://purl.obolibrary.org/obo/FMA_67408 Foundational Model of Anatomy LOOM
http://purl.obolibrary.org/obo/GO_0045202 Human Phenotype Ontology China LOOM
http://purl.obolibrary.org/obo/GO_0045202 Relations Ontology LOOM
http://purl.obolibrary.org/obo/GO_0045202 Phenotypic Quality Ontology LOOM
http://purl.obolibrary.org/obo/GO_0045202 Cell Ontology LOOM
http://purl.obolibrary.org/obo/GO_0045202 Gene Ontology LOOM