Type I Hypersensitivity

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3116

Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.

An immunoglobulin E (IgE) mediated hypersensitivity reaction. These usually occur within an hour of exposure to an allergen.

C3116

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118464

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C90259

NICHD

MedDRA

Immediate hypersensitivity reaction - type I reaction, involves immunoglobulin E (IgE)-mediated release of chemical mediators from mast cells and basophils. Th2 cells produce IL-4 and IL-13, which then act on B cells to promote the production of antigen-specific IgE. Reexposure to the antigen can then result in the antigen binding to and cross-linking the bound IgE antibodies on the mast cells and basophils. This causes the release of preformed mediators (histamine, tryptase, tryptase, chemotactic factors), newly synthesized mediators (leukotrienes, prostaglandin, thromboxane, platelet-activating factor, adenosine, bradykinin), and cytokines from these cells that results in structural and functional changes to the affected tissue.

Immediate hypersensitivity reaction

Type I Immediate Hypersensitivity Reaction

Type I Hypersensitivity Reaction

Type 1 Hypersensitivity

Immediate Hypersensitivity

Type 1 Hypersensitivity Reaction

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3114

Type I Hypersensitivity

Immediate_Hypersensitivity

Type I Immediate Hypersensitivity Reaction

Type I Hypersensitivity

C3116

Type I Hypersensitivity

Disease or Syndrome

C0020523

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3114