National Cancer Institute Thesaurus

Last uploaded: February 21, 2019
Preferred Name

Prolactin

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C778

ALT_DEFINITION

A hormone that is made by the pituitary gland (a pea-sized organ in the center of the brain). Prolactin causes a woman's breasts to make milk during and after pregnancy, and has many other effects in the body.

CAS_Registry

9002-62-4

code

C778

DEFINITION

Human prolactin (227 aa, 26 kDa precursor) is encoded by the human prolactin (PIT1) gene. This secreted lactogenic glycoprotein is expressed in both anterior pituitary lactotropes and the decidual endometrium. It acts primarily on the mammary gland and, in synergy with estrogen, induces progesterone release by corpus luteum cells to render the uterine mucosa suitable for implantation.

FULL_SYN

PRL

label

Prolactin

Legacy_Concept_Name

Prolactin

Preferred_Name

Prolactin

prefixIRI

C778

prefLabel

Prolactin

Semantic_Type

Hormone

UMLS_CUI

C0033371

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C752

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