loading...| Preferred Name |
tumor necrosis factor mediated signaling pathway |
| Synonyms |
TNFalpha signaling pathway TNF signaling pathway PID:200102 |
| Definitions |
Tumor necrosis factor (Tnf) signaling plays pivotal roles in immunity, cell proliferation, differentiation and apoptosis by activating several pathways. NF-kB is a major pathway activated by Tnf; others include JNK and P38 MAPK. Through receptor associated adapters Tnf elicits apoptosis via the extrinsic pathway. Deregulation of Tnf signaling has been implicated in a great number of human diseases - cerebral malaria, cancer, multiple sclerosis, are a few examples. |
| ID |
http://purl.obolibrary.org/obo/PW_0000233 |
| definition |
Tumor necrosis factor (Tnf) signaling plays pivotal roles in immunity, cell proliferation, differentiation and apoptosis by activating several pathways. NF-kB is a major pathway activated by Tnf; others include JNK and P38 MAPK. Through receptor associated adapters Tnf elicits apoptosis via the extrinsic pathway. Deregulation of Tnf signaling has been implicated in a great number of human diseases - cerebral malaria, cancer, multiple sclerosis, are a few examples. |
| has_obo_namespace |
pathway |
| has_related_synonym |
TNFalpha signaling pathway TNF signaling pathway PID:200102 |
| id |
PW:0000233 |
| label |
tumor necrosis factor mediated signaling pathway |
| notation |
PW:0000233 |
| prefLabel |
tumor necrosis factor mediated signaling pathway |
| treeView |
http://purl.obolibrary.org/obo/PW_0000926 |
| subClassOf |
http://purl.obolibrary.org/obo/PW_0000926 |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.obolibrary.org/obo/GO_0033209 | Human Phenotype Ontology China | LOOM | |
| http://purl.obolibrary.org/obo/GO_0033209 | Gene Ontology | LOOM |