loading...| Preferred Name |
circumventricular organ |
| Synonyms |
CVO circumventricular organ of neuraxis circumventricular organ |
| Definitions |
Any of any of the secretory or sensory organs located in the brain region around or in relation to the ventricular system that are characterized by extensive vasculature and a lack of a normal blood brain barrier (BBB) and allow for the linkage between the central nervous system and peripheral blood flow. |
| ID |
http://purl.obolibrary.org/obo/UBERON_0005408 |
| database_cross_reference |
MA:0002942 http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1242 NLXANAT:20090312 FMA:84081 EMAPA:35243 Wikipedia:Circumventricular_organs |
| definition |
Any of any of the secretory or sensory organs located in the brain region around or in relation to the ventricular system that are characterized by extensive vasculature and a lack of a normal blood brain barrier (BBB) and allow for the linkage between the central nervous system and peripheral blood flow. |
| depicted by |
http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray734.png |
| has_exact_synonym |
CVO circumventricular organ of neuraxis circumventricular organ |
| has_obo_namespace |
uberon |
| id |
UBERON:0005408 |
| in_subset | |
| label |
circumventricular organ |
| notation |
UBERON:0005408 |
| prefLabel |
circumventricular organ |
| UBPROP_0000008 |
All vertebrates possess at least 4 circumventricular organs (including the hypothalamus) which can monitor the contents of the cerebrospinal fluid and secrete additional substances into it. (Butler, 1996, p. 330) |
| UBPROP_0000010 |
CVOs contain neural tissue and are an integral part of neuroendocrine function; all of the CVOs, besides the subcommissural organ, contain extensive vasculature and fenestrated capillaries which leads to a leaky BBB at the site of the organs; the lack of a BBB allows CVOs to act as an alternative route for peptides and hormones in the neural tissue to the peripheral blood stream, while still protecting it from toxic substances |
| subClassOf |